http://mssm.technologypublisher.comBe the first to know about the latest inventions and technologies available from Mount Sinai School of Medicineen-USThu, 29 Jul 2010 13:21:52 GMTThu, 23 Jul 2009 12:50:40 GMThttp://blogs.law.harvard.edu/tech/rsstechnology@mssm.eduCopyright 2010, Mount Sinai School of Medicinehttp://mssm.technologypublisher.com/technology/3233in preparationThu, 23 Jul 2009 12:50:40 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/3233http://mssm.technologypublisher.com/technology/3232In preparationThu, 23 Jul 2009 12:50:39 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/3232http://mssm.technologypublisher.com/technology/3231in preparationThu, 23 Jul 2009 12:50:37 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/3231http://mssm.technologypublisher.com/technology/3230In preparationThu, 23 Jul 2009 12:50:35 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/3230http://mssm.technologypublisher.com/technology/3229In preparationThu, 23 Jul 2009 12:50:35 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/3229http://mssm.technologypublisher.com/technology/3228Thu, 23 Jul 2009 12:50:30 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/3228http://mssm.technologypublisher.com/technology/3227Background Currently, there are only four FDA-approved drugs available for treatment of influenza virus infection: the neuraminidase inhibitors (Tamiflu by Roche and Relenza by GSK), and the adamantanes (amantadine and rimantadine). For the influenza season 2008-2009, all isolated H3N2 viruses were resistant to the adamantanes while nearly all isolated H1N1 viruses, which have caused the majority of illness this season, were resistant to the neuraminidase inhibitors. The loss of effective therapy for influenza virus infections is significant, and therefore highlights the need for the developme...Thu, 23 Jul 2009 12:50:29 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/3227http://mssm.technologypublisher.com/technology/3226 Background Recent genetic studies have documented a pivotal growth-regulatory role played by the Cullin 7 (CUL7) E3 ubiquitin ligase complex containing the Fbw8-substrate-targeting subunit, Skp1, and the ROC1 RING finger protein. Investigators at the Mount Sinai School of Medicine have identified insulin receptor substrate 1 (IRS-1), a critical mediator of the insulin/insulin-like growth factor 1 signaling, as a proteolytic target of the CUL7 E3 ligase in a manner that depends on mammalian target of rapamycin and the p70 S6 kinase activities. Interestingly, while embryonic fibroblasts of Cul7...Thu, 23 Jul 2009 12:50:28 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/3226http://mssm.technologypublisher.com/technology/3225Thu, 23 Jul 2009 12:50:27 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/3225http://mssm.technologypublisher.com/technology/3224Background The human tumor suppressor p53, referred to as “guardian of the genome”, functions as a transcription factor to regulate expression of a large set of genes that induce cell cycle arrest or apoptosis in response to genotoxic injury. Chemotherapy and radiotherapy, two widely used therapies for cancer patients, are known to cause widespread p53-dependent DNA damage, which triggers potentially lethal pathologies that are generally deemed as unfortunate but unavoidable consequence. Recent pre-clinical studies using a mouse model revealed that p53-induced pathological response to whole-bo...Thu, 23 Jul 2009 12:50:22 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/3224http://mssm.technologypublisher.com/technology/3223Thu, 23 Jul 2009 12:50:20 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/3223http://mssm.technologypublisher.com/technology/3222In preparationThu, 23 Jul 2009 12:50:15 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/3222http://mssm.technologypublisher.com/technology/3221 Background KLF6 is a Kruppel like zinc finger transcription factor which is inactivated by allelic loss and somatic mutation in men with sporadic prostate cancer1. Since the original identification and description by MSSM investigators of the tumor suppressor KLF6 gene and its alternatively spliced “oncogenic” variant KLF6-SV1, these two related genes have been shown by us and others to be inactivated or their expression dysregulated in multiple human cancers, including prostate, ovarian, colorectal, non-small cell lung, gastric, hepatocellular, astrocytic glioma, pancreatic, and head and nec...Thu, 23 Jul 2009 12:50:14 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/3221http://mssm.technologypublisher.com/technology/3220In preparationThu, 23 Jul 2009 12:50:13 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/3220http://mssm.technologypublisher.com/technology/3219In preparationThu, 23 Jul 2009 12:50:08 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/3219http://mssm.technologypublisher.com/technology/3218In preparationThu, 23 Jul 2009 12:50:07 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/3218http://mssm.technologypublisher.com/technology/2714Mon, 08 Jun 2009 10:31:49 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2714http://mssm.technologypublisher.com/technology/2301Wed, 13 May 2009 13:20:33 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2301http://mssm.technologypublisher.com/technology/2060Fri, 10 Apr 2009 13:55:17 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2060http://mssm.technologypublisher.com/technology/2059Fri, 10 Apr 2009 13:55:16 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2059http://mssm.technologypublisher.com/technology/2058Fri, 10 Apr 2009 13:55:16 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2058http://mssm.technologypublisher.com/technology/2057Fri, 10 Apr 2009 13:55:15 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2057http://mssm.technologypublisher.com/technology/2056 AD is one of the most persistent and devastating disorders of old age, often leading to severe memory loss and functional impairment. It is estimated that up to ~ 5 million people in the US currently have AD at an estimated cost to society of greater than $100 billion per year. It is projected that up to 14 million people will be affected by AD by the middle of this century if successful therapies are not developed. At present, the few agents that are approved by the FDA for treatment of AD have demonstrated only modest effects in modifying clinical symptoms, and none has shown a clear eff...Fri, 10 Apr 2009 13:55:14 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2056http://mssm.technologypublisher.com/technology/2055 Hepatocellular carcinoma (HCC), a malignant tumor of the liver, is the third leading cause of cancer-related deaths, the leading cause of death among cirrhotic patients and it accounts for 80-90% of all liver cancers. HCC is notoriously refractory to treatment; when the tumors are small or slow-growing, surgery or liver transplant might be successful if the tumors are diagnosed early. However, because early tumors are difficult to distinguish from pre-neoplastic nodule lesions (such as high-grade dysplastic nodules), early diagnosis is difficult, a situation that has led to the search for mo...Fri, 10 Apr 2009 13:55:13 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2055http://mssm.technologypublisher.com/technology/2054Fri, 10 Apr 2009 13:55:12 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2054http://mssm.technologypublisher.com/technology/2053Fri, 10 Apr 2009 13:55:11 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2053http://mssm.technologypublisher.com/technology/2052Fri, 10 Apr 2009 13:55:10 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2052http://mssm.technologypublisher.com/technology/2051Fri, 10 Apr 2009 13:55:10 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2051http://mssm.technologypublisher.com/technology/2050 Contrary to the 20th century dogma, clotting can (and does) occur without damage to the vasculature, primarily due to action of circulating, or "blood-borne," Tissue Factor (TF). There are two known sources of circulating TF antigen: TF-positive membrane microparticles carrying encrypted full length TF, and lower MW soluble plasma TF molecules generated by alternative splicing (asTF). Of the two circulating TF forms, the former is mainly released upon cell damage/apoptosis, whereas the latter is constitutively secreted into blood by many components of the cardiovascular and endocrine systems,...Fri, 10 Apr 2009 13:55:09 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2050http://mssm.technologypublisher.com/technology/2049Fri, 10 Apr 2009 13:55:08 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2049http://mssm.technologypublisher.com/technology/2048Fri, 10 Apr 2009 13:55:07 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2048http://mssm.technologypublisher.com/technology/2047Fri, 10 Apr 2009 13:28:57 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2047http://mssm.technologypublisher.com/technology/2046Fri, 10 Apr 2009 13:28:56 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2046http://mssm.technologypublisher.com/technology/2045Fri, 10 Apr 2009 13:28:55 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2045http://mssm.technologypublisher.com/technology/2044 Stem cells are unique cells that have the ability for self-renewal and pluripotency, being able to differentiate into almost any type of cell/tissue. In recent years, the use and potential use of stem cells in the treatment of human diseases has grown exponentially. Researchers have made considerable progress in the search for methods that allow the generation of stem cells from other (specialized tissue) cells. When a patient needs a transplant, the ideal source is always his/her own cells (followed by a genetically related relative) in order for the risk of rejection of the transplant to be...Fri, 10 Apr 2009 13:28:55 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2044http://mssm.technologypublisher.com/technology/2043 Mouse mammary tumor virus (MMTV) is associated with a high incidence (over 90%) of breast cancer in certain strains of mice. MMTV acts as an insertional mutagen with several proviral insertion sites called int-1,2,3,4,5 and wnt-1, which are not expressed in normal mammary tissue but become activated after integration of MMTV provirus into the adjacent chromosomal DNA. The human homolog of int-2, located on chromosome 11, is amplified and expressed in 15% of breast cancers correlating with poor prognosis. The int-2 gene product shows homology to fibroblast growth factors. However, even thou...Fri, 10 Apr 2009 13:28:54 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2043http://mssm.technologypublisher.com/technology/2042 Congestive heart failure (CHF) is one of the leading causes of death in the world, with approximately 5 million people suffering from the condition in the United States alone. CHF is caused by any condition which reduces the efficiency of the heart muscle through tissue damage such as myocardial infarction. Because the heart tissue does not regenerate in adults, damaged heart muscle cells are often replaced with non-functional scar tissue causing progressive loss of function of the heart. Recent advances in ES cell research have shown that ES cell derived cardiomyocytes can be transplanted i...Fri, 10 Apr 2009 13:19:09 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2042http://mssm.technologypublisher.com/technology/2041 Current approaches to express genes in human ES cells have involved the use of viral vectors or transgenes that integrate randomly in the genome. These approaches have not been successful due in part because the randomly integrated vectors can activate or suppress endogenous gene expression, and/or the silencing of transgene expression. The problems associated with random integration have been overcome in part in the mouse ES cell system by homolgous recombination to a specific locus in the mouse genome known as Rosa26. The Rosa26 locus is easily accessible and amenable to homologous recombin...Fri, 10 Apr 2009 13:19:08 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2041http://mssm.technologypublisher.com/technology/2040 The embryonic layers ectoderm, mesoderm and definitive endoderm give rise to specific tissues and cell lineages through stages of differentiation during embryonic development. Mesoderm originates, among other tissues, blood cells and cardiac muscle. Notch signaling is involved in cell fate determination and differentiation and it is discovered in this invention to be involved in the specification of mesoderm to derivative lineages by playing a role in hematopoietic, vasculogenic and cardiac development. The present invention makes further use of this discovery and employs activated Notch to ...Fri, 10 Apr 2009 13:19:08 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2040http://mssm.technologypublisher.com/technology/2039Fri, 10 Apr 2009 13:19:07 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2039http://mssm.technologypublisher.com/technology/2038Fri, 10 Apr 2009 13:19:06 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2038http://mssm.technologypublisher.com/technology/2037 Recombinant adeno-associated virus vectors (rAAV) are widely used to transduce tissues in order to obtain stable expression of a cloned gene, this includes uses in gene therapy, one of its most popular applications. In order to obtain high expression, cotransfection is usually performed of the rAAV and a rep-cap plasmid into adenovirus-infected cell. MSSM research has identified a Cis-acting replication element (CARE) which linked to a gene of interest can be highly amplified in the presence of CARE-DRI (CARE-dependent replication inducers) and Rep proteins. In addition, by making use of the ...Fri, 10 Apr 2009 13:19:05 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2037http://mssm.technologypublisher.com/technology/2036Fri, 10 Apr 2009 12:36:19 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2036http://mssm.technologypublisher.com/technology/2035Fri, 10 Apr 2009 12:36:18 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2035http://mssm.technologypublisher.com/technology/2034Fri, 10 Apr 2009 12:36:17 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2034http://mssm.technologypublisher.com/technology/2033Fri, 10 Apr 2009 12:36:17 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2033http://mssm.technologypublisher.com/technology/2032Fri, 10 Apr 2009 12:36:14 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2032http://mssm.technologypublisher.com/technology/2031Fri, 10 Apr 2009 12:36:14 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2031http://mssm.technologypublisher.com/technology/2030 HIV therapy includes nucleoside analogues such as AZT. AZT as well as other antiviral compounds although efficacious, are highly toxic to patients. Since it is not known how such nucleoside analogues gain access into cells, it is difficult to address the issue of mitigating toxicity to these compounds. It has been thought that these antiviral agents, antisense oligonucleotides, and perhaps even plasmid gain access to cells via a channel protein. A discovery of such a channel would facilitate development of compounds that block this channel to potentially diminish toxicity associated with thes...Fri, 10 Apr 2009 12:36:13 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2030http://mssm.technologypublisher.com/technology/2029Fri, 10 Apr 2009 12:36:12 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2029http://mssm.technologypublisher.com/technology/2028Fri, 10 Apr 2009 12:36:12 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2028http://mssm.technologypublisher.com/technology/2027 Glaucoma is a severe eye disease which can cause progressive loss of vision eventually leading to blindness. The majority of human glaucomas are associated with increased intraocular pressure (IOP), which is considered the major risk factor for glaucomatous visual impairment resulting from the death of retinal ganglion cells. Several classes of drugs acting via different mechanism are administered topically as ocular therapy to lower IOP. Recently, a prostaglandin derivative has been introduced for glaucoma therapy, called latanoprost. The present invention provides prostaglandins belonging t...Fri, 10 Apr 2009 12:36:11 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2027http://mssm.technologypublisher.com/technology/2026 The inactivation by mutation of tumor suppressor gene families class I is known to contribute to oncogenicity of several types of human cancers. Another class of genes, class II, whose expression is down-regulated in tumor cells also encode potential tumor supressors, making them an attractive new target for cancer therapeutics. A new class II tumor suppressor gene, SSeCKSS has been shown to be downregulated in some transformed cells, a substrate of protein kinase C, and to act as a mitogenic regulator and an inhibitor of the transformed phenotype. Application The use of the tumor supresor ge...Fri, 10 Apr 2009 12:36:10 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2026http://mssm.technologypublisher.com/technology/2025 The hemagglutinin (HA) of influenza virus is the major surface antigen, exhibiting both receptor binding and fusion activities which are necessary for the initiation of viral infections. HA is also one of the best characterized membrane glycoproteins, showing several conserved cysteine residues which can be post-translationally modified by covalent addition of palmitic acids (palmitylation). The significance of palmitylation of viral proteins is not fully understood, with some data pointing to a requirement for infectivity. The authors of the invention present evidence for a role of the palmi...Fri, 10 Apr 2009 12:36:09 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2025http://mssm.technologypublisher.com/technology/2024Fri, 10 Apr 2009 12:36:08 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2024http://mssm.technologypublisher.com/technology/2023 Bromodomains (BRD) are defined protein motifs of about 110 amino acid residues that bind acetylated lysines (AcK) of different proteins, including histones. BrD/AcK binding plays important roles in eukaryotic chromatin remodeling and gene expression and in addition, in expression of some integrated viruses. Transcription of the integrated HIV provirus requires cellular transcription factors and the specific viral protein Tat. Tat is trans-activated via acetylation of its lysine 50, which then binds the BRD of the coactivator PCAF. This interaction of TatAcK50/PCAF, important for HIV transcrip...Fri, 10 Apr 2009 11:27:08 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2023http://mssm.technologypublisher.com/technology/2022 Obsessive-compulsive spectrum disorders include a variety of impulsive, compulsive and pervasive developmental disorders (PDDs) ranging from obsessive compulsive disorder to eating disorders, impulse control and movement disorders, and autism. Autism belongs to a group of PPDs including also ADD, ADHD and Asperger’s. Autism, unlike Alzheimer’s disease, is a neurodevelopmental disorder rather than a neurodegenerative disease, characterized by difficulties in social interaction, speech and communication, and by compulsive, repetitive behaviors. Memantine has been approved by the FDA for treatme...Fri, 10 Apr 2009 11:27:08 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2022http://mssm.technologypublisher.com/technology/2021 A large percentage of the population of the US and Europe is affected by allergic reactions to a variety of environmental allergens, making atopic disorders one of the most prevalent in the industrialized world. Allergic reactions are immune reactions initiated by IgE-dependent stimulation of basophils, mast cells and dendritic cells via binding through its specific, high affinity receptor FCeRI which may be cross-linked on the cell surface initiating a cascade of cellular signals that result in the physiological manifestations of the allergic reaction in response to the allergen initially bo...Fri, 10 Apr 2009 11:24:53 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2021http://mssm.technologypublisher.com/technology/2020 The influenza virions consist of an internal ribonucleoprotein core containing a segmented single-stranded RNA genome encoding about ten polypeptides, and an outer lipoprotein envelope. Transcription and replication of the genome occurs in the nucleus and assembly via budding on the plasma membrane. Influenza virus adsorbs via HA to cell membrane glycoproteins and glycolipids. Following endocytosis, the nucleocapside migrates to the nucleus where viral mRNA is transcribed by a unique mechanism producing eight viral RNAs encoding ten proteins; two of the transcripts generate two mRNAs each via...Fri, 10 Apr 2009 11:24:52 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2020http://mssm.technologypublisher.com/technology/2019 Alzheimer’s disease (AD) is a dementia syndrome with defects in areas of cognition and progressive worsening of memory and cognition over time. However, by the time these physiological changes may be seen, significant irreversible neuronal damage has already occurred. The structural, chemical and functional abnormalities in an AD’s patient brain are also difficult to asses in a live patient until the disease has progressed to undesirable levels. Parkinson’s disease (PD) is a chronic nervous disease characterized by uncontrolled tremors, which generally occurs gradually. There is no effective ...Fri, 10 Apr 2009 11:20:12 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2019http://mssm.technologypublisher.com/technology/2018Fri, 10 Apr 2009 11:20:10 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2018http://mssm.technologypublisher.com/technology/2017Fri, 10 Apr 2009 11:20:10 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2017http://mssm.technologypublisher.com/technology/2001Thu, 09 Apr 2009 21:00:31 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2001http://mssm.technologypublisher.com/technology/2000Molecular umbrellas are molecules that consist of amphiphilic structures which can interconvert between two different morphological states in response to environmental changes. The current invention is on the use of persulfated molecular umbrellas to facilitate transport across phospholipids bilayers. The researchers have shown that such compounds exhibit anti-viral activity in vitro against immunodeficiency virus (HIV) and herpes simplex virus (HSV). These two viruses, each one of very high incidence and of public health importance, exhibit infectious synergistic relationships, which undersco...Thu, 09 Apr 2009 21:00:30 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/2000http://mssm.technologypublisher.com/technology/1999Diffuse malignant gliomas are cancerous brain tumors that invade the surrounding normal tissue by an aggressive diffusion process that affects the prognosis adversely and renders radical treatment impossible. Although the state of the art medical imaging improved the detection of gliomas, the quantification of the invasion, prediction of their behavior and surgical removal remain a challenge. Current mathematical models to quantify and analyze cancer tumors at the cellular level are not scalable due to their enormous complexity in the number of equations or algorithms needed. This invention pr...Thu, 09 Apr 2009 21:00:30 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1999http://mssm.technologypublisher.com/technology/1998Within mammalian cells, different components interact with one another to form sub-cellular local networks that come together to form a single large network. The individual activities of the various components need to be coordinated in order to achieve the cohesiveness needed for cellular functions, for which information is required to flow between the components in a continuous and organized manner. The present invention, applying graph theory analysis (a field focused on qualitative relationships between components of a network) provides a computer-aided system and method for the analysis of...Thu, 09 Apr 2009 21:00:29 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1998http://mssm.technologypublisher.com/technology/1997Thu, 09 Apr 2009 21:00:29 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1997http://mssm.technologypublisher.com/technology/1996 Background The function of adhesion receptors in both cell adhesion and migration depends critically on interactions with the cytoskeleton. During cell adhesion, cytoskeletal interactions stabilize receptors to strengthen adhesive contacts. In contrast, during cell migration, adhesion proteins are believed to interact with dynamic components of the cytoskeleton, permitting the transmission of traction forces through the receptor to the extracellular environment. The L1 cell adhesion molecule (L1CAM), a member of the Ig superfamily, plays a crucial role in both the migration of neuronal growth...Thu, 09 Apr 2009 21:00:28 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1996http://mssm.technologypublisher.com/technology/1995Microarray hybridization of mRNAs is commonly used to determine whether genes are up- or down-regulated in response to the specific condition. However, RNA hybridization to genome-wide microarrays has proven expensive and not highly reproducible, with serious issues regarding statistical significance of the results. The current invention introduces a “focused microarray analysis” (FMA) approach by selecting a subset of genes of interest to generate a microarray that contains triplicates of each gene. Hybridizing RNAs via FMA results in better statistical significance of the results obtained wi...Thu, 09 Apr 2009 21:00:27 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1995http://mssm.technologypublisher.com/technology/1994Thu, 09 Apr 2009 21:00:27 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1994http://mssm.technologypublisher.com/technology/1993 Background Liver fibrosis is the result of an imbalance between production and dissolution of extracellular matrix. Stellate cells, portal myofibroblasts, and bone marrow derived cells converge in a complex interaction with hepatocytes and immune cells to provoke scarring in response to liver injury. Uncovering the specific effects of growth factors on these cells, defining the interaction of different cell population during liver fibrosis and characterizing the genetic determinants of fibrosis progression will enable the discovery of new therapeutic approaches. Dendritic cells, cytolytic cel...Thu, 09 Apr 2009 20:37:45 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1993http://mssm.technologypublisher.com/technology/1992Thu, 09 Apr 2009 20:37:44 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1992http://mssm.technologypublisher.com/technology/1991Thu, 09 Apr 2009 20:37:43 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1991http://mssm.technologypublisher.com/technology/1990Thu, 09 Apr 2009 20:37:43 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1990http://mssm.technologypublisher.com/technology/1989Thu, 09 Apr 2009 20:37:42 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1989http://mssm.technologypublisher.com/technology/1988 Background Microtubules are highly dynamic assemblies of a-tubulin. One essential function of microtubules is to partition duplicated chromosomes equally into two daughter cells during cell division. When cells enter mitosis, microtubule dynamics increase up to 100 fold compared to while in interphase. The half time of exchanging spindle tubulin with tubulin in the free tubulin pool is about 10 seconds. This high speed dynamic is very sensitive to interferences, and is therefore a moving target in tumor cells for many chemotherapeutic agents, such as vinca alkaloids, nocodozoles and paclitaxe...Thu, 09 Apr 2009 20:37:41 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1988http://mssm.technologypublisher.com/technology/1987 Inflammation is an immune response to injury as well as pathogens and irritants. Characterized by redness, swelling, and pain, inflammation results when immune cells and proteins exude from blood vessels into surrounding tissue to repair injury. Additionally, multiple biochemical pathways amplify the inflammatory response. Deregulation of the inflammatory response can result in numerous inflammatory diseases including rheumatoid arthritis, diabetic retinopathy, psoriosis, and macular degeneration. Angiogenesis, the development of new blood vessels, has recently been linked to inflammation as ...Thu, 09 Apr 2009 20:37:40 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1987http://mssm.technologypublisher.com/technology/1986Thu, 09 Apr 2009 20:37:40 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1986http://mssm.technologypublisher.com/technology/1985Thu, 09 Apr 2009 20:37:39 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1985http://mssm.technologypublisher.com/technology/1984Thu, 09 Apr 2009 20:37:38 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1984http://mssm.technologypublisher.com/technology/1983Thu, 09 Apr 2009 20:15:22 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1983http://mssm.technologypublisher.com/technology/1982A major obstacle in therapy of pancreatic cancer and several other solid tumors is the inefficient delivery of therapeutics due to poor vascularization and hypoxic cores of some solid tumors. These same conditions, however, offer an ideal environment for anaerobic bacteria colonization and tumor destruction. This invention provides genetically enhanced anaerobic bacteria for the oncopathic therapy of cancers, including pancreatic and other cancers that contain avascular, hypoxic regions. Genetically enhanced anaerobic bacteria contain one or more modifications to decrease oxygen tolerance of b...Thu, 09 Apr 2009 20:15:22 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1982http://mssm.technologypublisher.com/technology/1981Thu, 09 Apr 2009 20:15:21 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1981http://mssm.technologypublisher.com/technology/1980Thu, 09 Apr 2009 20:15:20 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1980http://mssm.technologypublisher.com/technology/1979Thu, 09 Apr 2009 20:15:20 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1979http://mssm.technologypublisher.com/technology/1978Thu, 09 Apr 2009 20:15:19 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1978http://mssm.technologypublisher.com/technology/1977 To combat counterfeiting, there is an ever-increasing need for reliable techniques for specific identification and marking of various types of valuable property, including currency, identification papers and cards, and valuable objects and liquids such as antiques, industrial parts, perfumes, oil, etc. A number of techniques for carrying out DNA-based marking have been described and patented. However, these DNA-based approaches suffer from a number of technical limitations; e.g., low signal-to-noise ratios. More significantly, the existing marking techniques do not conceal the DNA "code" empl...Thu, 09 Apr 2009 20:15:18 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1977http://mssm.technologypublisher.com/technology/1976Thu, 09 Apr 2009 20:15:17 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1976http://mssm.technologypublisher.com/technology/1975Thu, 09 Apr 2009 20:15:16 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1975http://mssm.technologypublisher.com/technology/1974Thu, 09 Apr 2009 20:15:16 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1974http://mssm.technologypublisher.com/technology/1973Thu, 09 Apr 2009 19:52:33 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1973http://mssm.technologypublisher.com/technology/1972 Background Autocrine Wnt signaling in the mouse mammary tumor virus model was the first identified mechanism of canonical pathway activation in cancer. In search of this transformation mechanism in human cancer cells, investigators at the Mount Sinai School of Medicine identified breast and ovarian tumor lines with upregulation of the uncomplexed transcriptionally active form of beta-catenin without mutations affecting downstream components. Extracellular Wnt antagonists FRP1 and DKK1 caused a dramatic downregulation of beta-catenin levels in these tumor cells associated with alteration of bi...Thu, 09 Apr 2009 19:52:33 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1972http://mssm.technologypublisher.com/technology/1971Thu, 09 Apr 2009 19:52:32 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1971http://mssm.technologypublisher.com/technology/1970Thu, 09 Apr 2009 19:52:31 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1970http://mssm.technologypublisher.com/technology/1969Thu, 09 Apr 2009 19:42:52 GMTtechnology@mssm.eduhttp://mssm.technologypublisher.com/technology/1969